Medicine Supply Notification: Disopyramide (Rythmodan Retard® ) 250mg modified-release tablets and disopyramide (Rythmodan® ) 100mg capsules. Updated

1st July 2024: Updates to the further information hosted on the Medicines Supply Tool,  have been published. 


Department of Health and Social Care (DHSC) has issued a medicine supply notification for Disopyramide (Rythmodan Retard®) 250mg modified-release tablets and disopyramide (Rythmodan®) 100mg capsules.

MSN/2024/075

Tier 2 – medium impact

Date of issue: 5th June 2024

  • Disopyramide (Rythmodan Retard®) 250mg modified-release tablets are out of stock until mid-July 2024.
  • Disopyramide (Rythmodan®) 100mg capsules will be out of stock from mid-July 2024 until mid-January 2025.
  • From mid-July, disopyramide (Rythmodan Retard®) 250mg modified-release tablets can support a partial increase in demand.
  • Alternative treatments to disopyramide remain available (see Supporting information).
  • Unlicensed imports of disopyramide 100mg capsules and disopyramide 250mg MR tablets have been sourced, lead times vary (see Supporting information)
  • Unlicensed specials of disopyramide 25mg/5ml & 50mg/5ml oral suspension are available, lead times vary (see Supporting information).

Unlicensed products

The following specialist importers have confirmed they can source unlicensed disopyramide 100mg capsules and 250mg MR tablets. Please note there may be other companies that can also source supplies:

The following specials manufacturers have confirmed they can source unlicensed disopyramide liquid (25mg/5ml and or 50mg/5ml oral suspension). Please note there may be other companies that can also source supplies:

If there is currently no listing on dm+d for the imported product for prescribers to select using their prescribing systems an EPS prescription for the unlicensed product cannot be issued. Where a prescriber wishes to prescribe a specially manufactured or imported product, an FP10 paper prescription should be issued as ‘ Disopyramide xx (Special Order)’ and endorsed by the pharmacy as a non-Part VIIIB special with the following information:

  • Amount dispensed over pack size used;
  • Invoice price per pack size from which the order was supplied less any discount or rebate;
  • Manufacturers’/importers’ MHRA licence number;
  • Batch number of the product supplied;
  • SP

A copy of this medicine supply notification, including further information, has been sent to all pharmacy NHS email addresses.

DHSC and NHSE/I have now launched an online which provides up to date information about medicine supply issues. The contents of these MSNs can now be viewed on the Tool.

The Tool also details any changes to resupply dates and updates to the entries.

To access the Tool you will need  an NHS email address. Once set up and logged in, you will be able to access it online.

New shortages not listed on the SPS website, can be reported using our shortage reporting tool.

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