Medicine Supply Notification: Estradiol (Lenzetto® ) 1.53mg/dose transdermal spray

Department of Health and Social Care (DHSC) has issued a medicine supply notification for Estradiol (Lenzetto®) 1.53mg/dose transdermal spray.


Tier 2 – medium impact

Date of issue 23rd May 2022

  • Estradiol (Lenzetto®) 1.53mg/dose transdermal spray is in limited supply until mid-July 2022.
  •  Three Serious Shortage Protocols (SSP) were issued on 20/05/2022 to allow community
    pharmacists to limit supply to three months or where supplies of estradiol (Lenzetto®) 1.53mg/dose
    transdermal spray are unavailable, to supply estradiol patches which remain available.
  • Where this is not appropriate, alternative hormone replacement therapies also remain available.
  •  Where the above alternatives are not suitable, unlicensed supplies can be sourced, lead times vary

The following specialist importers have confirmed they can source unlicensed Lenzetto® 1.53mg/dose
transdermal spray (please note there may be other companies that can also source supplies):

When prescribing a product that is not licensed in the UK due to a supply issue with the licensed alternative
prescribers must indicate on the FP10 prescription that an unlicensed product is required. This can be done
in one of the following two ways:

Electronic prescriptions – if the required unlicensed product is shown on electronic prescribing
systems, GPs should select:

  • Lenzetto® 1.53mg/dose transdermal spray (imported)

Paper prescriptions – where the unlicensed product is not shown on electronic prescribing systems,
GPs should use a paper prescription and annotate with the following wording: “special order

A copy of this medicine supply notification, including further information, has been sent to all pharmacy NHS email addresses.

DHSC and NHSE/I have now launched an online Medicines Supply Tool, which provides up to date information about medicine supply issues. The contents of these MSNs can now be viewed on the Tool.

The Tool also details any changes to resupply dates and updates to the entries.

To access the Tool you will need  an NHS email address. Once set up and logged in, you will be able to access it online.

New shortages not listed on the SPS website, can be reported using our shortage reporting tool.

Support the call for more funding by recording information about the informal advice you provide to patients over just one day.

Click Here