Medicine Supply Notification: Estradiol (Progynova® TS) 50micrograms/24hours and 100micrograms/24hours transdermal patches

The Department of Health and Social Care (DHSC) has issued a medicine supply notification for the following product:

• Estradiol (Progynova® TS) 50micrograms/24hours and 100micrograms/24hours transdermal patches

MSN/2025/048

Tier 2 – medium impact

Date of issue: 06/08/2025

• Progynova^® TS 50micrograms/24hours and 100micrograms/24hours transdermal patches (once weekly estradiol patches) will be discontinued from late December 2025 and February 2026, respectively.
• FemSeven^® 50micrograms/24 hours and 100micrograms/24 hours transdermal patches (once-weekly estradiol patches) remain available and can support the increase in demand.
• Evorel^® 50micrograms and 100micrograms and Estraderm® MX 50micrograms and 100micrograms transdermal patches (twice-weekly estradiol patches) remain available and can support the increase in demand

A copy of this medicine supply notification, including actions required and supporting information, has been sent to all pharmacy NHS email addresses.

DHSC and NHSE/I have now launched an online Medicines Supply Tool, which provides up to date information about medicine supply issues. The contents of these MSNs can now be viewed on the Tool.

The Tool also details any changes to resupply dates and updates to the entries.

To access the Tool, you will need an NHS email address. Once set up and logged in, you will be able to access it online.

New shortages not listed on the SPS website can be reported using our shortage reporting tool.