Medicine Supply Notification: Estradiol valerate/medroxyprogesterone acetate (Indivina® ) 1mg/5mg tablets

Department of Health and Social Care (DHSC) has issued a medicine supply notification for Estradiol valerate/medroxyprogesterone acetate (Indivina®) 1mg/5mg tablets.


Tier 2 – medium impact

Date of issue 14th September 2023

  • Estradiol valerate/medroxyprogesterone acetate (Indivina®) 1mg/5mg tablets are out of stock until w/c 11th December 2023.
  • Alternative continuous combined hormone replacement therapies (HRT) containing estradiol 1mg but a different progesterone component remain available and will be able to support increased demand
  • Estradiol valerate/medroxyprogesterone acetate (Indivina®) 1mg/2.5mg tablets remain available but cannot support uplift in demand.
  • Where alternatives are not suitable, unlicensed supplies may be sourced, lead times vary.

Unlicensed products

The following specialist importers have confirmed they can source unlicensed Indivina 1mg/5mg tablets (please note there may be other companies that can also source supplies):

If there is currently no listing on dm+d for the imported product for prescribers to select using their prescribing systems an EPS prescription for the unlicensed product cannot be issued. Where a prescriber wishes to prescribe a specially manufactured or imported product, an FP10 paper prescription should be issued as ‘ Indivina 1mg/5mg tablets (Special Order)‘ and endorsed by the pharmacy as a non-Part VIIIB special with the following information:

  • Amount dispensed over pack size used;
  • Invoice price per pack size from which the order was supplied less any discount or rebate;
  • Manufacturers’/importers’ MHRA licence number;
  • Batch number of the product supplied;
  • SP

A copy of this medicine supply notification, including further information, has been sent to all pharmacy NHS email addresses.

DHSC and NHSE/I have now launched an online Medicines Supply Tool, which provides up to date information about medicine supply issues. The contents of these MSNs can now be viewed on the Tool.

The Tool also details any changes to resupply dates and updates to the entries.

To access the Tool you will need  an NHS email address. Once set up and logged in, you will be able to access it online.

New shortages not listed on the SPS website, can be reported using our shortage reporting tool.

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