Medicine Supply Notification: Midazolam (Epistatus® ) 2.5mg/0.25ml and 10mg/1ml oromucosal solution pre-filled oral syringes

Department of Health and Social Care (DHSC) has issued a medicine supply notification for Midazolam (Epistatus®) 2.5mg/0.25ml and 10mg/1ml oromucosal solution pre-filled oral syringes.

MSN/2023/086

Tier 2 – medium impact

Date of issue 14th September 2023

  • Midazolam (Epistatus®) 2.5mg/0.25ml and 10mg/1ml oromucosal solution pre-filled oral syringes are out of stock until late November 2023.
  • Midazolam (Buccolam® and generic) 2.5mg/0.5ml oromucosal solution pre-filled oral syringes remain available and will be able to support increased demand.
  • Midazolam (Buccolam®) 10mg/2ml oromucosal solution pre-filled oral syringes remain available and will be able to support increased demand.
  • Generic midazolam 10mg/2ml oromucosal solution pre-filled oral syringes remain available but are unable to support an increase in demand.

Please note an MHRA medicine recall was issued for Epistatus® 2.5mg oromuscosal solution, prefilled syringes on 30th August 2023.

A copy of this medicine supply notification, including further information for pharmacy teams, has been sent to all pharmacy NHS email addresses.

DHSC and NHSE/I have now launched an online Medicines Supply Tool, which provides up to date information about medicine supply issues. The contents of these MSNs can now be viewed on the Tool.

The Tool also details any changes to resupply dates and updates to the entries.

To access the Tool you will need  an NHS email address. Once set up and logged in, you will be able to access it online.

New shortages not listed on the SPS website, can be reported using our shortage reporting tool.

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